targeted相关论文
Postsynthetic modifications of zinc-carboxylate nanoscale metal-organic frameworks for targeted drug
Given the high potential of metal-organic frameworks (MOFs) to be used as delivery carriers for drug molecules, it is cr......
Folic Acid-Conjugated Hollow Mesoporous Silica/CuS Nanocomposites as a Difunctional Nanoplatform for
In this work,we have developed a novel difunctional nanoplatform for targeted chemo-photothermal therapy based on hollow......
Nanodiamond is a promising type of biomaterial for therapeutic applications.Here, we use nanodiamond (ND) as a platform ......
The 300 GHz band, which is one of terahertz frequency bands, has low atmospheric attenuation and can be used for communi......
Multiple myeloma(MM) is an incurable cancer.However,recent advances have been made,which not only enhances understanding......
Auxin acts as a key hormone in plant that determines many developmental processes by the typical concentration dependent......
An engineered PD-1-based and MMP-2/9-oriented fusion protein exerts potent antitumor efficacy agains
Recent studies have shown that PD-1/PD-L1 checkpoint blockade is a dramatic therapy for melanoma through enhancing antit......
Genetic diversity analysis of sugarcane germplasm collections based on a start codon targeted polymo
Sugarcane is the most important sugar and energy crop,representing more than 77%of the total sugar production and over 7......
Application of Paclitaxel-loaded EGFR Peptide-conjugated Magnetic Polymeric Liposomes for Liver Canc
Developing the methodologies that allow for safe and effective delivery of therapeutic drugs to target sites is a very i......
Objective:To analyze and evaluate the clinical efficacy of targeted navel drops in the treatment of diabetes mellitus.Me......
【Abstract】From the practical need of current college English elective course construction and on the basis of the theo......
Elite capture,the“follow-up checks”policy,and the targeted poverty alleviation program:Evidence from
Decentralized methods for targeting poverty are widely adopted in developing countries to improve the performance of var......
Extrahepatic metastasis(EHM)of hepatocellular carcinoma(HCC)has increasingly been seen due to improved survival with eff......
“The Source of Flowing Water”:How Targeted Poverty Alleviation Helps China’s Rural Poor Access Credi
Based on the China Household Finance Survey(CHFS)data of 2011-2017,this paper investigated the effects of China’s targe......
Hepatocellular carcinoma(HCC)is one of the most common malignant tumors in the world.The treatment methods for HCC are d......
Although targeted therapies and immunotherapies have been effective againstseveral malignancies, the respective monother......
The potential of miRNA-based therapeutics in severe acute respiratory syndrome coronavirus 2(SARS-Co
Since the World Health Organization(WHO) declared COVID-19, the disease caused by severe acute respiratory syndrome coro......
Nanomedicines for the treatment of rheumatoid arthritis:State of art and potential therapeutic strat
Increasing understanding of the pathogenesis of rheumatoid arthritis(RA)has remarkably promoted the development of effec......
Tumors of the breast,prostate,and lung are most likely to metastasize to the bone and typically indicates a poor cure an......
Targeted heat treatment of additively manufactured Ti-6Al-4V for controlled formation of Bi-lamellar
Laser powder bed fusion(L-PBF)was utilized to produce specimens in Ti-6Al-4V,which were subjected to a bi-lamellar heat ......
COVID-19: Considerations about immune suppression and biologicals at the time of SARS-CoV-2 pandemic
The extent of the profound immunological and nonimmunological responses linked to severe acute respiratory syndrome coro......
The Initial Errors in the Tropical Indian Ocean that Can Induce a Significant “Spring Predictability
Initial errors in the tropical Indian Ocean(IO-related initial errors) that are most likely to yield the Spring Predicti......
Targeting FGFR in non-small cell lung cancer:implications from the landscape of clinically actionabl
Objective:Dysfunction in fibroblast growth factor receptor(FGFR)signaling has been reported in diverse cancer types,incl......
Current evidence and challenges of systematic therapies for adult recurrent glioblastoma: Results fr
Recurrence is a major concern for adult patients with glioblastomas(GBMs), and the prognosis remains poor.Although sever......
Paclitaxel-loaded and folic acid-modified PLGA nanomedicine with glutathione response for the treatm
Targeted delivery and smart response of nanomedicine hold great promise for improving the therapeutic efficacy and allev......
Objective To investigate the genetic causes of sudden sensorineural hearing loss(SSNHL)patients in China.This study focu......
The RAS/mitogen-activated protein kinase(MAPK)pathway disorder induced by the missense mutations in the tyrosine-protein......
Carbon nanomaterials have garnered much concern because of their potential applications in bioimaging,p hotocatalysi......
The natural history of cirrhosis varies and therefore prognostic prediction is critical given the sizable patient popula......
Prussian blue nanoparticle-loaded microbubbles for photothermally enhanced gene delivery through ult
By adsorbing chitosan(CS)-functionalized Prussian blue(PB) nanoparticles(CS/PB NPs) complexing DNA onto the surface of g......
In this study, novel liver targeted doxorubicin (DOX) loaded alginate (ALG) nanoparticles were prepared by CaCl2 crossli......
Metastatic colorectal cancer (mCRC) continues to be counted as a major health problem. The introduction of newer cytotox......
Design and synthesis of novel coumarin analogs and their nematicidal activity against five phytonema
The presence of hydroxyl groups at the C4 and C7 positions in coumarin backbone has been proposed as a potential modific......
在神经管缺损(NTD)低危人群中,血清甲胎蛋白(MSAFP)作为筛查试验,其目的是找出某些孕妇尚需进一步作较昂贵或具有危险性的诊断检......
Prednisolone succinate-glucosamine conjugate:Synthesis,characterization and in vitro cellular uptake
Prednisolone succinate-glucosamine(PSG) conjugate,a prodrug for prednisolone,was synthesized and confirmed by NMR and MS......
In order to develop a novel kidney-targeted drug delivery system,a small molecular carrier(2-deoxy-2-aminodiglucose) was......
Design,synthesis and antiproliferative activities of diaryl urea derivatives bearing N-acylhydrazone
A new series of diaryl urea derivatives bearing N-acylhydrazone moiety were designed and synthesized.All the target comp......
Aminopeptidase N(APN) is an important drug target and biomarker for various tumors.The current work characterizes a nove......
Synthesis and antibacterial activity of novel[1,2,4]triazolo[3,4-h][1,8]naphthyridine-7-carboxylic a
Novel tricyclic fluoroquinolones,[1,2,4]triazolo[3,4-h][1,8]naphthyridine-8-one-7-carboxylic acid derivatives 4a-4h bear......
Heat stress can stimulate an increase in body temperature,which is correlated with increased expression of heat shock pr......
The complicated, highly dynamic and diverse nature of biosystems brings great challenges to the specific analysis of mol......
Design, synthesis and biological evaluation of novel dicarbonylalkyl piperazine derivatives as neuro
In the search of novel neuroprotective agents with higher potency than our previously identified antiischemic stroke dru......
Layer by layer surface engineering of poly (lactide-co-glycolide) nanoparticles:A versatile tool for
Recent work regarding the Layer by Layer (LbL) engineering of poly(lactide-co-glycolide) nanoparticles (PLGA NPs) is rev......
Magnetic Fe3O4 nanoparticles were synthesized by co-precipitation method and the mercaptopurine(MER) drug-loaded magneti......
To explore the preparation of PLGA ceftiofur hydrochlorate lung-targeted microsphere with spray drying process, the prep......
With the support by the National Natural Science Foundation of China and the Chinese Academy of Sciences,the research te......
General urban design is targeted at the urban environment, which includes identifying the relationship between landscape......
The incidence of invasive fungal infections is increasing rapidly.Clinically available antifungal agents suffer from lim......
The novel bone-targeted agents were designed and synthesized by the combination of raloxifene and bisphosphonates. The a......
A series of drug delivery systems based on a sodium alginate derivative were prepared by mixing glycyrrhetinic acid(GA) ......
